This paper makes a comprehensive analysis of geological characteristics, ore characteristics of the Xie Jiaba pb-zn deposit of Guizhou Province. According to the “Mississippi” type ore deposits on the identification of the comparison and analysis, this paper also explores the Xiejiaba deposit genetic type, and summarizes the ore-prospecting criteria, so as to provide a theoretical basis for the prospecting exploration in the future. The pb-zn orebody occurs in the Dengying group on the sinian system in the upper part of the dolomite strata, along the Shangmuchang field output anticline axis direction, and is strictly controlled by strata, fault. It is mainly lead and zinc ore, barite and fluorite associated. The wall rock alteration includes four types, i.e. pyrite, strong weak dolomitization, barite, weak silicification. As to the main metallogenic model for fluid migration-mixed mode, prospecting marks are mainly stratigraphic, structural marks, surface outcrop mineralization. It is the geological characteristics, ore deposit, ore characteristics and Sichuan-Yunnan-Guizhou region group of Yangtze massif, comparing with the formation characteristics of pb-zn deposit. The comparison results show that the Xiejiaba pb-zn deposit genetic types is “Mississippi” type ore deposit, namely the MVT type deposit.