In order to better use the deep-hole blasting, to optimize the parameters is especially important. According to the actual situation of the Zhengjiapo Iron Mine, this paper, through the orthogonal experiment method, adopts the fan vertical deep hole by row blasting technology, and analyzes several main parameters of the deep hole blasting before and after optimization. The relative blast parameters for deep-hole blasting are confirmed. This technology is of referential values for other similar iron mines.