In order to determine the reasonable design of truss and anchor rope parameters in soft rock roadway, this paper, based on the theoretical analysis, the FLAC3D numerical simulation and the SPSS orthogonal experiment method, together with the practical Mukong Coal Mine geological environment, has optimized the prestressed truss and anchor rope in soft rock roadway support parameter, which can give a full play to truss anchor cable combined supporting ability and avoid supporting material waste and the high cost of supporting. Field observations indicate that the largest value of the two sides moving closer is 145 mm. The roof subsidence maximum is 166 mm. Roadway surrounding rock convergence rate is within the valid range. Support of truss and anchor rope can improve the overall stability of roadway surrounding rock with good results.