The Zunyi manganese ore is the national self-contained manganese exploration area. In recent years, the Zunyi manganese ore is national ready exploration area of Guizhou Province. Through continuous exploration and comprehensive study, this paper uses the theory to guide exploration practice, has major prospecting breakthroughs in the study area, and finds several large manganese ore bed. On the basis of previous studies, this paper makes an analysis from Zunyi manganese ore, lithofacies palaeogeographic characteristics, metallogenic environment and diagenetic phase transformation. This paper holds that Zunyi manganese ore zone is distributed in the late Permian in brussel mouth sets trench facies belt, generally showing a concentric circle. Outside in respectively is pyrite phase clay rock gully edge phase taigou groove center, among which the taigou groove center is in manganese concentration, and has the big value. Manganese ore in the area is formed in weak alkaline, REDOX, and relatively closed metallogenic environments. Firstly, the heat needed for the ore forming process is mainly derived from magma activity; secondly, it is probably related to the area in the ancient geothermal anomaly high value area. Diagenetic stage of transformation is also an important factor of Zunyi manganese mineralization. This paper provides the theoretical basis for further research of manganese ore and metallogenic mechanism.