Aiming at the big ventilation resistance that exists in the Bayi Coal Mine in the process of deep mining, insufficient amount of wind supply and high tunneling face temperature, this paper conducts the determination of mine ventilation technology. Results show that the mine actual quantity is 62 m3/s, lower than the cost of 100 m3/s, for a serious shortage of the wind. In addition, the total ventilation resistance is 2 712 Pa, which is close to mine ventilation resistance limit. In ventilation system into the wind, and with the wind and return air resistance ratio at 2∶1∶11.8, the resistance distribution is not reasonable. According to the production deployment and the air distribution situation during the easy and the difficult period of the mine ventilation, this paper puts forward the technical measures in two aspects. On the one hand, it optimizes the mine ventilation system by enabling parallel airway, reducing air leakage rate of mine and expanding brush roadway section, etc., so as to reduce the mine wind resistance; on the other hand, it replaces the existing fan and improves the ventilation. After optimizing the ventilation system, and reducing the mine wind resistance, it uses the computer to calculate and analyze the different periods of the main mine ventilator models, which are finally determined.