Because the method of selecting mine cooling system lacks of systematic evaluation method and quantitative analysis method, this paper proposes a new optimization method of mine cooling system, which applies AHP to build a hierarchy structure model of mine cooling system optimization index system, and give every weighting coefficient by analytic hierarchy process. Combined with the fuzzy comprehensive evaluation, it builds evaluation set and judgment matrix according to the comprehensive score. By taking Liuzhuang Coal Mine as an example and by using the optimized method of hierarchical analysis and fuzzy comprehensive evaluation, the paper selects the underground centralized refrigeration cooling system. After the measures have been carried out, the temperature of coal face decreases significantly by reducing about 7.5 ℃. Results show this is a scientific and objective method, which can provide reasonable references for optimization of the schemes and possess certain practical value.